Akynzeo Injection is an anti-emetic medication containing a fixed-dose combination of two active ingredients, such as fosnetupitant and palonosetron. Fosetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. This medication is used to prevent chemotherapy-induced nausea and vomiting (CINV). It is prescribed to help cancer patients to better tolerate their chemotherapy treatments by reducing the likelihood of these distressing side effects and is also used to control postoperative nausea and vomiting.

The common side effects that are likely to occur with this medicine are hives, swollen face, breathing trouble, and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. If you have liver problems or renal impairment, discuss this with your physician. Dosing adjustments may be necessary in such cases. There is a potential risk of serotonin syndrome when Akynzeo Injection is combined with other serotonergic medications. Serotonin syndrome can cause symptoms such as agitation, hallucinations, rapid heartbeat, fever, muscle stiffness, and coordination problems. Inform your physician about all medications, including antidepressants and other serotonergic drugs, that you are taking.

The safety and efficacy of Akynzeo Injection in pediatric patients have not been established. It is primarily intended for use in adults. It is unsafe to administer this drug to pregnant women because it may cause harm to the baby. Please consult your doctor before taking this medicine. It is unclear whether this drug passes into breast milk for breastfeeding women, and consulting a doctor for guidance would be a better choice.

Chemotherapy-induced nausea and vomiting.

Postoperative nausea and vomiting.

Akynzeo Injection is a fixed-dose combination of two active ingredients, fosnetupitant and palonosetron. Fosnetupitant is a neurokinin-1 (NK-1) receptor antagonist, while palonosetron is a 5-HT3 receptor antagonist. Together, they work by blocking specific receptors in the brain and gut that trigger nausea and vomiting, providing more effective control of these side effects.

The medicine can be given only as an intravenous injection into a vein by your physician in a hospital setting. Akynzeo Injection is usually administered as a 30-minute infusion before you receive your anti-cancer medicine (chemotherapy) or right before anesthesia for surgery.

Allergic reactions

Hives

Swollen face

Breathing trouble

Chest pain

Headache

Fatigue

Dizziness

Abdominal pain

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Akynzeo Injection and reduce effectiveness by causing undesirable side effects.

Store Akynzeo Injection below 25°C.

Do not freeze.

Keep it out of reach of children and pets.

Proper hydration can help reduce the risk of CINV. Drink plenty of fluids, and inform your physician if you have difficulty keeping fluids down. Try to maintain a balanced diet when possible. Eating small, frequent meals and snacks throughout the day can help prevent nausea and vomiting. Stress and anxiety can worsen nausea. Engage in relaxation techniques, such as deep breathing exercises or meditation, to help manage stress. Adequate rest and sleep are also important during the treatment with Akynzeo Injection.