Amphonex 50mg injection contains the active substance Liposomal Amphotericin B. It is an antifungal antibiotic. It is used to treat fungal infections of one or more deep body organs. It is also used to treat suspected fungal infections in patients with a raised temperature and neutropenia (reduced number of white blood cells). It is also indicated to treat visceral leishmaniasis, a disease caused by a parasite in certain people.  

Before initiating your first treatment, your physician may give you a small amount of Amphonex 50mg injection to check for allergic reactions. Do not receive this injection if you are allergic to amphotericin B or any of the other ingredients in the medicine. Inform your physician if you have a severe allergic reaction, kidney or liver problems, and if you are having dialysis. Tell your doctor if you have low potassium levels. 

This medicine contains sugar in each vial; tell your doctor if you have diabetes. Inform your physician if you are pregnant or breastfeeding before initiating the treatment. The most common side effects of Amphonex 50mg injection are skin rash, low potassium levels, diarrhea, anemia, insomnia, and shortness of breath. This medicine is not recommended for babies under 1 month old.

Fungal infections of one or more deep organs of the body

Suspected fungal infections

Visceral leishmaniasis

Amphonex 50mg injection binds primarily to ergosterol in sensitive fungi cell membranes, causing membrane permeability changes that result in leakage of intracellular contents and cell death.

A doctor or nurse in a hospital or clinic setting will give it to you. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.

Skin rash

Increased blood sugar levels

Decreased potassium levels

Diarrhea

Nausea, vomiting

Anemia

Insomnia

Shortness of breath

Fever, chills or shivering

Cardia arrest

GI bleeding

Severe skin reactions

Acute kidney injury

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Amphonex 50mg injection and reduce its effectiveness by causing undesirable side effects.

Do not store above (25°C)

keep the injection away from the reach of children and pets.

If you have missed any dosing appointments, inform your doctor and schedule immediately.

This medicine may cause damage to the kidney. Inform your doctor if you have kidney problems. This injection may cause severe infusion reactions such as flushing, itching, sickness, swelling of the face, mouth, tongue and airways, difficulty breathing. Inform your physician immediately if you face any of these symptoms. It may be necessary to continue this medication for several weeks to several months in order to treat certain infections. Stopping the medication too early may result in a return of the infection. Tell your doctor if your condition lasts or gets worse.