Avastin 400mg Injection is an anticancer medicine consisting of the active ingredient Bevacizumab. This medicine is developed to prevent the growth of tumors. It is indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used to treat cancers of the ovary, fallopian tube, or primary peritoneal cancer. Use effective birth control during the treatment and for at least six months after the last dose. Avastin 400mg Injection is not recommended for adolescents and children under the age of 18. Discuss with your doctor about the preservation of ovaries if you are planning for pregnancy in the near future, as this medicine may cause fertility issues in women. It would be best to avoid breastfeeding your baby, as this medicine may interfere with growth and development.

Avastin 400mg Injection is often administered in combination with other chemotherapy agents. Constipation, appetite loss, runny nose, fever, skin problems, and weight loss are common side effects of Avastin 400mg Injection. Before starting treatment with this medicine, let your doctor know if you have high blood pressure, high blood sugar, stomach disorders, or heart problems. This medicine should not be taken for 28 days before and after surgery, as it is associated with poor wound healing and high bleeding complications. It is advised to report to your doctor if you have any dental issues that require surgery before taking this medicine. In case you develop any visual changes or confusion, report to your doctor to prevent complications.

Glioblastoma multiforme (brain cancer)

Persistent, recurrent, or metastatic breast cancer

Metastatic cervical cancer

Advanced kidney cancer

Metastatic colorectal cancer

Advanced non-small-cell lung cancer

Liver Cancer—Hepatocellular carcinoma

Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Bevacizumab is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumor. As a result, it slows down the rate of progression of cancer.

Your physician or nurse will administer Avastin 400mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

Headache

Vision changes

Confusion

Severe allergic reactions

High Blood pressure

Delayed wound healing following surgery

Protein in urine

Severe infections

Blood clots in arteries and blood vessels of lungs

Gut perforation

Nosebleeds and bleeding risk

Heart problems with an increase in heart rate

Mouth sores, dryness

Shortness of breath

Numbness in hands or feet

Weakness and lack of energy

Diarrhoea, nausea, vomiting, abdominal pain

Constipation

Loss of appetite

Weight loss

Changes in taste and speech

Decrease in counts of white blood cells

Fever

Dry skin

Back pain

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional and vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Avastin 400mg Injection and cause undesirable side effects.

Store Avastin 400mg Injection at 2°C to 8°C.

Do not freeze or shake.

Protect from light. Keep out of reach of children.

It is vital to inform your physician before taking Avastin 400mg Injection if you have the following conditions:

Have conditions involving inflammation in the stomach (ulcer, colitis).

Experience allergic reactions to Avastin 400mg Injection or its ingredients.

Have recently undergone surgery as it is associated with the risk of bleeding.

Have diabetes, hypertension, or heart problems.