Aveva injection contains the active substance fulvestrant. It is an antineoplastic drug that belongs to the class estrogen receptor antagonist. Estrogen, a type of female sex hormone, can sometimes be involved in the growth of breast cancer. This medicine is used alone to treat postmenopausal women with a certain type of breast cancer called estrogen receptor-positive breast cancer that is locally advanced or spread to other parts of the body. It is also indicated in combination with other anti-cancer medication to treat women with certain types of breast cancer called hormone receptor-positive, human epidermal growth factor receptor 2-negative breast cancer, which is locally advanced or spread to other parts of the body. 

Do not take this injection if you are allergic to fulvestrant or any other ingredients of this medicine, pregnant or breastfeeding, or have severe liver problems. Before initiating the treatment, inform your physician if you have kidney or liver problems, bone diseases, bleeding disorders, and heart diseases. Aveva injection is not indicated in children and adolescents under 18 years. Report to your physician if you have allergic reactions, including swelling of the face, lips, tongue, or throat, after administering this injection.

This injection may increase your risk of bleeding and liver failure. Female patients of reproductive potential should use effective contraception during treatment with this injection and for two years after the last dose.

Treat women with certain types of breast cancer

Treat Hormone receptor (HR)-positive

Human epidermal growth receptor 2 (HER2)-negative breast cancer in postmenopausal women.

Many breast cancers have estrogen receptors (ER), and the growth of these tumors can be stimulated by estrogen. Aveva injection is an estrogen receptor antagonist that binds to the estrogen receptors in cancer cells and works by blocking the action of estrogen on cancer cells. This can slow or stop the growth of tumor cells.

It should only be administered by a trained doctor or nurse as a slow intramuscular injection. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors.

Constipation, diarrhea

Loss of appetite

Nausea, vomiting

Decreased RBC, WBC, and Platelets

Infections

Joint and muscle pain

Backache, bone pain

Weakness, tiredness

Headache

Cough, difficulty breathing

Hot flushes

Pain at the site of injection

Changes in heart rhythm

Severe neutropenia(decreased WBC)

Liver failure, inflammation of liver

Hypersensitivity reaction

Swelling in the body

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Aveva injection and reduce its effectiveness by causing undesirable side effects.

Store Aveva injection in the refrigerator (2°C to 8°C)

Do not freeze

keep the injection away from the reach of children and pets.

If you have missed any dosing appointments, inform your doctor and schedule immediately.

Inform your physician if you have vaginal bleeding, especially at starting of the therapy. This medicine is given as a shot into one of your muscles. Aveva injection should be used with caution in patients with severe kidney disease. This medicine needs to be given on a fixed schedule; if you miss a dose, inform your doctor immediately. Do not breastfeed during treatment and for one year after your last dose. This medicine may cause infertility. Talk to your doctor before using this medicine if you plan to have children.