Bavencio 200mg injection 10ml contains the active ingredient avelumab. It is an antineoplastic drug that belongs to the class of medications called PD-1/PD-L1 (programmed death ligand-1) inhibitors. It is used to treat Merkel cell carcinoma, a rare type of skin cancer that has spread to other body parts in adults and children 12 years and older. It is also indicated to treat urothelial carcinoma, cancer that originates in the urinary tract and has spread to nearby tissues or other body parts of the body in people whose cancer worsened during or within 12 months after it was treated with other anticancer medications.  

It is also used in combination with other anticancer medicines to treat renal cell carcinoma, a type of kidney cancer that has spread to other body parts. PD-L1 is found on the surface of certain cancer cells and helps protect them from the immune system. It works by slowing or stopping the growth and spread of the cancer cells. Do not take Bavencio 200mg injection 10ml if you are allergic to avelumab or any other ingredients of this medicine. Inform your physician if you have liver diseases, hepatitis B, HIV/AIDS, or other immune diseases before initiating the therapy. 

Merkel cell carcinoma

Urothelial carcinoma

Renal cell carcinoma

Avelumab is a monoclonal antibody (a type of protein) that attaches to a specific target in the body called PD-L1. It binds to PD-L1 and blocks this protective effect, allowing the immune system to attack the tumour cells. It also induces antibody-dependent cell-mediated cytotoxicity, ultimately leading to cancer cell death.  

It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. It is given as an intravenous infusion drip (into your vein). This will take one hour. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors. 

Increased blood pressure

Swelling in the legs and feet

Skin rash

Abdominal pain

Decrease in appetite

Diarrhea

Nausea

Decreased RBC counts

Muscle pain

Cough, shortness of breath

Difficulty in talking

Tiredness 

Heart problems

Severe skin reactions

Thyroid problems

Liver injury

Visual impairment

Infusion reactions

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Bavencio 200mg injection 10ml and reduce its effectiveness by causing undesirable side effects. 

Store in a refrigerator (2°C to 8°C).

Do not freeze. Store in the original package to protect from light.

keep the injection away from the reach of children and pets.

If you have missed any dosing appointments, inform your doctor and schedule immediately.

Report symptoms of infection, anemia, or bleeding immediately to your doctor. Do not breastfeed during the treatment and for 1 month after the last dose. Inform your doctor if you have kidney disease, liver disease, heart disease, diabetes, lung or breathing problems, or stomach problems before initiating the therapy. Do not stop taking the injection without consulting the physician. Stopping your treatment may stop the effect of the medicine. Your doctor may ask you to do certain tests to check for the effectiveness of the therapy and to monitor any unwanted side effects.