Bespona 1mg injection is an anticancer medication with an active ingredient called Inotuzumab ozogamicin. It is used to treat adults with acute lymphoblastic Leukemia. It is intended when patients have failed to respond to other treatments. Acute lymphoblastic Leukemia (ALL) refers to the accumulation of white blood cells that have not matured due to the abnormal production of white blood cells in the bone marrow.  

Do not take Bespona 1mg injection if you are allergic to Inotuzumab ozogamicin or any other ingredients of this medicine, if you have or have any history with any liver disease, such as venoocculusive disease (damaged liver blood vessels), cirrhosis, nodular regenerative hyperplasia (signs and symptoms of portal hypertension due to chronic use of medicine), or active hepatitis (inflammation of the liver) and blood clot. This medicine is not recommended for children and adolescents.  

Acute lymphoblastic Leukemia

Inotuzumab ozogamicin targets a protein called CD22, which is commonly expressed by blood cancer (ALL) cells. After attaching to this protein, this medicine disturbs the DNA of the cancer cells and eventually kills them.

A trained doctor or nurse should only administer it. Do not self-administer the Bespona 1mg injection. Your doctor will decide the dose and duration of your treatment based on the disease severity and other factors. It will be given as an intravenous infusion, and you will be monitored carefully for unwanted side effects. 

Breathing trouble

Chills

Rapid weight gain

Abnormal liver function values

Frequent bleeding and bruising

Infusion-related reaction (fever, chill, breathing trouble)

Venoocclusive liver disease (rapid weight gain, right upper abdomen pain, swelling of the liver)

The lower number of blood cells

Tumor lysis syndrome

Changes in the electrical activity of the heart

Anaemia

Tiredness

Infection

Bleeding

Fever

Nausea

Headache

Abnormal blood values

Stomach pain

High bilirubin value

Low appetite

Mouth inflammation

Constipation

Diarrhea

Swelling of abdomen

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional, supplements, and herbal products. In particular, tell your doctor if you are taking medicines for blood pressure or other heart conditions. Certain medications may interact with Bespona 1mg injection and reduce its effectiveness by causing undesirable side effects. 

Store Bespona 1mg injection in the refrigerator (2°C to 8°C)

Do not freeze

keep the injection away from the reach of children and pets.

If you have missed any dosing appointments, inform your doctor and schedule immediately.

Dose adjustments will be made based on the response to the treatment. Pre-medicine will be given to reduce the infusion reactions, keep hydrated, and prevent tumour lysis syndrome and other side effects. There is limited information on the safety of Bespona 1mg injection in renal failure patients; inform your physician if you have kidney disease. Notify your doctor if you experience any side effect symptoms, as your doctor may change the dosage of this medicine or give additional medicine to reduce the effect of the side effects. Men should use effective contraception during and after the last dose of the treatment.