Bortenat 2mg Injection is a chemotherapy medication that belongs to the class of medicines called proteasome inhibitors. It consists of the active ingredient Bortezomib. It is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma refers to the cancerous progression of plasma cells that are predominant in the bone marrow. Mantle cell lymphoma is a less common cancer affecting the lymph nodes. This medication is concomitantly used with other chemotherapy medicines like pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide for patients who have not started treatment and are ineligible for blood stem cell transplant. 

Inform your doctor if you are allergic to Bortenat 2mg Injection and its ingredients. Do not use this medication if you have severe lung or heart problems. Before starting treatment with this medication, let your physician know if you are suffering from neuropathy (nerves malfunction), cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumor lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Inform your doctor of diabetes because this Injection can affect your blood glucose levels.

Treatment of multiple myeloma and mantle cell lymphoma.

Bortenat 2mg Injection Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication.

Bortenat 2mg Injection is administered intravenously in your vein or subcutaneously under the skin. This injection should be given by a qualified healthcare professional experienced in the use of cytotoxic medications. Do not self-administer.

Muscle cramps

Confusion, visual disturbances, seizures, and headache

Breathlessness

Swelling of feet

Changes in heartbeat

High blood pressure

Fainting and tiredness

Cough and chest tightness

Pneumonia

Loss of appetite

Sensitivity, tingling and burning sensation of the skin

Nausea, vomiting, and diarrhea

Mouth ulcers

Constipation

Muscle and bone pain

Hair loss

Fever

Reduction in blood cell count

Reduced kidney function

Shivering

Infections

Itching and redness

Dehydration

Stomach problems

Difficulty sleeping, anxiety, mood swings, depressed mood

Inform your doctor about any prescribed medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Bortenat 2mg Injection and may cause undesirable side effects.

Store unopened vials in the refrigerator (2 °C – 8 °C) and protect them from light.

Keep this medicine out of sight and reach of children.

It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with Bortenat 2mg Injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with bortezomib to check your blood cell counts regularly. Pregnant women should not handle this Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.