Borviz 2.5mg Injection is a chemotherapy medication that belongs to the class of medicines called proteasome inhibitors. It consists of the active ingredient Bortezomib. It is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma refers to the cancerous progression of plasma cells that are predominant in the bone marrow. Mantle cell lymphoma is a less common cancer affecting the lymph nodes. This medication is concomitantly used with other chemotherapy medicines like pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide for patients who have not started treatment and are ineligible for blood stem cell transplant.

• Treatment of multiple myeloma and mantle cell lymphoma.

Borviz 2.5mg Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signalling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication.

Borviz 2.5mg Injection is administered intravenously in your vein or subcutaneously under the skin. This injection should be given by a qualified healthcare professional experienced in the use of cytotoxic medications. Do not self-administer.

• Muscle cramps
• Confusion, visual disturbances, seizures, and headache
• Breathlessness
• Swelling of feet
• Changes in heartbeat
• High blood pressure
• Fainting and tiredness
• Cough and chest tightness
• Pneumonia
• Loss of appetite
• Sensitivity, tingling and burning sensation of the skin
• Nausea, vomiting, and diarrhea
• Mouth ulcers
• Constipation
• Muscle and bone pain
• Hair loss
• Fever
• Reduction in blood cell count
• Reduced kidney function
• Shivering
• Infections
• Itching and redness
• Dehydration
• Stomach problems
• Difficulty sleeping, anxiety, mood swings, depressed mood

Inform your doctor about any prescribed medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Borviz 2.5mg Injection and may cause undesirable side effects.

• Store unopened vials in the refrigerator (2 °C – 8 °C) and protect them from light.
• Keep this medicine out of sight and reach of children.

It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with Borviz 2.5mg Injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with bortezomib to check your blood cell counts regularly. Pregnant women should not handle this Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.