Brukinsa 80mg Capsule is a prescription medicine used to treat certain types of blood cancers. It contains Zanubrutinib, which belongs to a class of drugs called BTK inhibitors. These medicines work by blocking a protein that helps cancer cells grow and survive, so they slow down or stop the spread of cancer in the body.

Doctors usually prescribe Brukinsa 80mg Capsule to people who’ve already had other treatments for blood cancer. It’s taken by mouth and usually comes as a capsule. While it can be effective, it’s not suitable for everyone. People with serious liver problems, certain heart issues, or women who are pregnant or breastfeeding should not use this medicine unless a doctor says it’s safe.

Before starting the treatment, your doctor will do some blood tests to make sure the medicine is right for you. They’ll also check your health regularly during the treatment to make sure everything stays on track.

Brukinsa 80mg Capsule is FDA-approved for the treatment of:

Mantle Cell Lymphoma (MCL)—in adults who’ve had at least one previous treatment.

Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL).

Waldenström’s Macroglobulinemia (WM).

Marginal Zone Lymphoma (MZL)—after treatment with an anti-CD20 medicine.

Follicular Lymphoma (FL)—limited use or under review in some places.

Zanubrutinib targets a protein in the body called BTK, which helps cancer cells survive and grow. By blocking this protein, the medicine weakens the cancer cells, making it harder for them to multiply. Over time, this can help shrink the cancer or stop it from spreading.

It doesn’t cure cancer, but it helps manage it and may improve how you feel and function during treatment.

You can take Brukinsa 80mg Capsule by mouth, usually once or twice a day, depending on your doctor’s advice. You can take it with or without food, but make sure to take it around the same time each day. Swallow the capsule whole; don’t crush or chew it.

Diarrhea

Muscle pain

Cough

Rash

Low white blood cell count

Tiredness

Bruising easily

Serious infections (fever, chills, shortness of breath)

Bleeding or blood in stool/urine

Irregular heartbeat or chest pain

Liver problems (yellowing of skin or eyes)

Severe allergic reactions (swelling, rash, difficulty breathing)

Some medicines can interact with Brukinsa 80mg Capsule, making it less effective or increasing the risk of side effects. Make sure to tell your doctor about all medicines, vitamins, or herbal supplements you’re taking.

Here are some serious interactions to be aware of:

Strong antifungals or antibiotics (like ketoconazole or clarithromycin) can raise the levels of Zanubrutinib in your body, which may cause side effects.

Medicines that lower Zanubrutinib levels, like rifampin or phenytoin, might make it less effective.

Blood thinners (like warfarin or clopidogrel) can increase your risk of bleeding.

Heart rhythm drugs, or medications that affect the heartbeat, can lead to complications when taken together with Zanubrutinib.

Live vaccines should be avoided during treatment and for a while after stopping the medicine.

Always check with your doctor before starting any new medication.

Store the medicine at room temperature (20 - 25°C), away from moisture and heat.

Keep the medicine out of reach of children and pets.

Do not share your medication with others, even if they have similar symptoms.

Take it at the same time daily—this helps maintain a steady level of the medicine in your body for better effectiveness.

Avoid grapefruit and grapefruit juice—they can interfere with how the medicine works and may increase side effects.

Watch for signs of infection—fever, chills, or cough should be reported to your doctor immediately, as the medicine can weaken your immune system.

Don’t skip medical checkups— Regular blood tests are important to monitor blood counts, liver function, and how well the treatment is working.

Tell your doctor about all medicines you're taking—especially blood thinners, antibiotics, and antifungals, as they may interact with Brukinsa 80mg Capsule.