Cladrim 10mg injection is an antineoplastic drug belonging to the category of medicines known as purine analogues, containing the active ingredient Cladribine. It is used in the treatment of Multiple Sclerosis (is a type of autoimmune disorder that affects the nervous system). It is also used to treat Hairy cell leukemia (cancer of white blood cells). 

This drug is contraindicated in patients with current malignancies, active chronic infections like tuberculosis or hepatitis, and for those with a history of hypersensitivity reactions. High doses of this drug have been associated with the irreversible neurologic toxicity (paraparesis/quadriparesis), acute nephrotoxicity, and severe bone marrow suppression resulting in neutropenia, anemia and thrombocytopenia. Clinicians should also monitor patients frequently for signs and symptoms of neurological impairment, such as numbness or tingling in the arms or legs, weakness, or loss of bowel or bladder control. If these symptoms occur, urgent treatment is necessary to prevent further neurological damage. It is essential to inform your doctor if you have a history of any bleeding disorders, liver or kidney disease, or if you're taking any other medications, including over-the-counter drugs, supplements, or herbal remedies. 

Consult your doctor before using this medication if you are pregnant or plan to have a baby. This medicine is not recommended for pregnant women as it may cause fetal harm. Your health care practitioner will conduct a pregnancy test before you start treatment with this Injection. This medicine may cause birth defects if either partner uses it during conception or pregnancy. Male patients with female partners of reproductive potential should use effective birth control during the treatment and for 3 months after the last dose. Do not breastfeed during the treatment and for 10 days after the last dose. Avoid vaccination with live-attenuated or live vaccines during and after the treatment with this drug while the patient’s white blood cell counts are not within normal limits.

Multiple sclerosis.

Hairy cell leukemia.

It is a purine analog drug, which means it mimics the structure of purines (the building blocks of DNA). When this drug binds into the DNA of cancer cells, it interferes with DNA synthesis and repair, leading to the accumulation of damaged DNA and leads to cell death.

It should only be administered by a trained doctor or nurse experienced in giving chemotherapy. This drug can be administered either as an intravenous (IV) infusion or as a subcutaneous injection. When given as an IV infusion, the drug is administered over a period of two hours. When given as a subcutaneous injection, the drug is administered under the skin using a small needle. Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity and other factors.

Septic shock (infection throughout the body)

Malignancies

Anemia

Renal failure

Bleeding

Depressed level of consciousness

Neurotoxicity

Infection

Low white blood cells

Allergic reactions

Administration site reaction

Confusion, Anxiety, Insomnia

Headache, dizziness

Eye infection

Abnormal heart rate

Cough, abnormal breath sounds

Nausea, vomiting

Abdominal pain, constipation, diarrhea

Buildup of gas

Rash, itchiness

Chills

Loss of appetite

Pain, joint pain

Fatigue, muscle weakness

Swelling in the hands and feet

Inflammation of vein

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Cladrim 10mg injection and reduce effectiveness by causing undesirable side effects.

Store Cladrim 10mg injection in a refrigerator at (2°C to 8°C).

Keep it out of reach from children.

Avoid contact with people who have infections, especially during the time when you are taking the medication. Limit direct skin contact with the tablets, and wash exposed areas thoroughly. Your doctor will perform regular blood tests during treatment with this drug to monitor the blood cell counts and kidney function. Let your doctor know about any other medications you are taking, including over-the-counter drugs, supplements, or herbal remedies.