Ibrunat 140mg Capsule consists of the active ingredient Ibrutinib. It is indicated to treat blood cancers such as mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL), small lymphocytic lymphoma (CLL), Waldenstrom’s macroglobulinemia, and Marginal zone lymphoma (MZL). These are cancers of the white blood cells called lymphocytes that are part of the immune system. They differ from each other by the location where cancer occurs, type of lymphocytes affected, and certain other factors

Ibrunat 140mg Capsule is also used to treat chronic graft versus host disease (cGvHD ) after the failure of systemic therapy. During allogeneic stem cell transplantation, the patient receives stem cells from the donor. GvHD occurs when donor cells view the patient’s cells as foreign and attack them. Before taking Ibrutinib Capsule, you need to talk with your physician if you have bleeding problems, infection, liver problems, heart problems, or intolerance to some sugars. This medication is not recommended for adolescents and children. 

It is vital to let the physician know if you have recently had or are about to have any surgical procedure. Your physician may stop Ibrunat 140mg Capsule for any planned surgical or medical procedure.

Mantle cell lymphoma

Chronic lymphocytic leukemia (Blood cancer)

Small lymphocytic lymphoma

Waldenstrom’s macroglobulinemia

Chronic graft vs. host disease after failure of systemic therapy

The mechanism of action of Ibrunat 140mg involves blocking a specific protein called Bruton's tyrosine kinase (BTK) which plays a key role in the survival and growth of cancer cells. By inhibiting BTK, Ibrunat 140mg prevents the cancer cells from receiving the signals they need to grow and divide, leading to their eventual death.

Consume Ibrunat 140mg at the same time each day. While taking Ibrunat 140mg, do not consume grapefruit or orange in any form during the treatment. Drink plenty of fluid to prevent dehydration.

Bleeding problems

Infections

Decrease in blood cell counts

Heart problems

High BP

Secondary cancer

Tumor lysis syndrome

Severe allergic reactions

Nausea, vomiting, diarrhea

Tiredness

Muscle and bone pain

Rash and bruising

Mouth sores

Pneumonia

Fever, chills

Breathlessness

Constipation

Dizziness

Body pain

Swollen ankles and feet

Increased creatinine levels in blood

Heavier periods and blood in urine

Blurred vision

Weakness and numbness

Inform your healthcare professional about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interacting with Ibrunat 140mg , may reduce effectiveness by causing undesirable side effects.

Store the capsules in the original packaging at room temperature (20-25°C).

Contact your doctor immediately if you experience bleeding, infection, shortness of breath, or chest discomfort. Report to your doctor if you have had a history of heart failure or hepatitis infection. It is not recommended to take this medicine before or after surgery as it causes a delay in wound healing. Discuss effective contraceptive options with your healthcare provider and use them during treatment and for a month after the last dose of Ibrunat 140mg.