Jakavi 15mg tablet contains the active constituent Ruxolitinib. It is an anticancer agent that belongs to the class of kinase inhibitors. It is used to treat myelofibrosis ( a rare type of bone marrow cancer that causes decreased blood cell production). It is also used to treat polycythemia vera (a type of blood cancer where the body produces too many red blood cells) in people who are resistant or cannot be treated successfully with other medications (hydroxyurea). The medicine is also indicated to treat acute graft versus host disease (a complication of transplant procedure that replaced diseased bone marrow with healthy bone marrow) previously treated unsuccessfully with steroid medications in adults and children 12 years of age. It is also used for treating chronic graft versus host disease in adults and children 12 years of age and older who were treated unsuccessfully with 1 or 2 other systemic treatments. 

Jakavi 15mg tablet works by blocking the signals that cause cancer cells to multiply. Do not take this medicine if you are allergic to ruxolitinib or any other ingredients in this medicine. Inform your physician priory if you have or had tuberculosis, hepatitis B or C, liver disease, and kidney problems. The most common adverse effects are dizziness, reduced blood counts, bruising, bleeding, headache, and facial and body swelling. Notify your physician if you are on dialysis.

Myelofibrosis.

Polycythemia vera.

Acute-graft-versus host disease.

Chronic-graft-versus host disease.

Ruxolitinib, a kinase inhibitor, inhibits dysregulated Janus Associated Kinase (JAK) 1 and JAK2 signaling associated with myelofibrosis and polycythemia vera. By blocking certain enzymes, this medicine can reduce the serious risk of blood or vascular complications in myelofibrosis and polycythemia vera. In GvHD, it reduces the signs and symptoms, improving the disease and survival of transplanted cells.

Your doctor will decide the dose and duration of Jakavi 15mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.

Severe infections like hepatitis B

Anemia

Bleeding

Low red and white blood cell counts

Low platelet counts

Dizziness, headache

Bruising

Diarrhea

Infections including viral infection

Swelling in the face and body

Fatigue or tiredness

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, and supplements and herbal products. Certain medications like fluconazole and other CYP3A4 inhibitors may interact with Jakavi 15mg tablet and reduce its effectiveness by causing undesirable side effects.

Do not store this medicine above 30°C.

Keep the medicine out of reach from children and pets.

If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

You should continue taking this tablet until your doctor says since, it is a long-term treatment. Do not stop taking Jakavi 15mg tablet or reduce its dose without consulting a physician. Inform your physician if you get any infection or symptoms of bleeding during the treatment. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Wash your hands often. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Inform your doctor if you are a smoker or a past smoker.