Lorbriqua Lorlatinib 100mg Tablet 15's

Lorbriqua tablet is a drug belonging to the class of tyrosine kinase inhibitors, containing the active ingredient Lorlatinib. It is used to treat metastatic non-small cell lung cancer (NSCLC). This is the most common type of lung cancer. Metastatic non-small cell lung cancer (NSCLC) is a type of lung cancer that has spread to other parts of the body, such as the bones, liver, brain, or other organs.

It is meant for adults whose cancer is ALK-positive, meaning the tumor carries a change in the ALK gene confirmed by a lab test, and it works by blocking the abnormal ALK protein that drives the tumor's growth.

During the treatment, your doctor may periodically monitor your white blood cell counts, platelets, blood sugar, electrolytes, and kidney parameters to prevent serious complications. This medicine has the potential to cause liver damage. Also, it may cause decreased fertility in males, which could affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility. 

Inform the doctor if you have been diagnosed with liver disorders, heart failure, high blood cholesterol levels, or hypertension before starting this treatment. Report to your doctor if you experience any hypersensitive reactions like itchy skin or rashes while taking this medicine. It is advised to avoid drinking grapefruit juice while taking this drug, as it may increase the level of the drug in the blood and cause side effects.

This tablet contains lactose as an inactive ingredient, which the body is unable to digest. Lactose is a sugar found in milk and dairy products. It can cause symptoms such as bloating and abdominal pain. If you have lactose intolerance, inform your doctor before starting this therapy.

Metastatic non-small cell lung cancer (NSCLC).

It works by inhibiting the tyrosine kinases, thus preventing the activation of downstream signaling pathways that are involved in cell proliferation, survival, and differentiation. This leads to the inhibition of cancer cell growth and survival.

Your doctor will decide the dose and duration of Lorbriqua Tablet based on your disease condition and other factors. Take the tablet at the same time every day, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forget to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Serious:

Cough, chest pain, or worsening of breathing problems

Feeling tired, faint, or losing consciousness

Yellowing of the skin and eyes, vomiting, abdominal pain

Confusion, memory loss, mood swings, difficulty speaking, seeing, or hearing things that are not real

Common:

• Increase in cholesterol levels
• Swelling in hand or legs
• Double vision difficulty seeing
• Pain, numbness, or unusual sensations (burning or pinpricks) in arms and legs, difficulty walking
• Diarrhea, constipation
• Headache
• Weight gain
• Joint pain, muscle pain
• Rash
• Anemia
• Increase in cholesterol levels
• Swelling in hand or legs
• Double vision difficulty seeing
• Pain, numbness, or unusual sensations (burning or pinpricks) in arms and legs, difficulty walking
• Diarrhea, constipation
• Headache
• Weight gain
• Joint pain, muscle pain
• Rash

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Lorbriqua Tablet and reduce effectiveness by causing undesirable side effects.

• Store the Lorbriqua Tablet in the original package at controlled room temperature (20°C to 25°C).
• Keep it out of reach from children.

It is not recommended for pregnant women, as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment. Discuss effective non-hormonal contraceptive methods with your healthcare provider, use them during this treatment, and continue for at least six months after the last dose. It is not known if the Lorbriqua Tablet passes into the breast milk. Hence, breastfeeding during this treatment is not recommended. This medicine may increase your blood sugar levels. Your healthcare provider should do blood tests to check your blood sugar levels before starting and during treatment with this drug. It is important to start or change your medicine to control your blood sugar levels. Report to your doctor right away if you get new or worsening signs and symptoms of high blood sugar, such as feeling thirsty, confused, and tired. This tablet might cause breathing difficulty and problems with thinking. Hence, it is advisable to avoid driving or operating machines during this treatment. Before starting this treatment, inform your doctor if you are taking any prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.