Lorbriqua 25mg tablet is a drug belonging to the class of tyrosine kinase inhibitors, containing the active ingredient Lorlatinib. It is used to treat metastatic non-small cell lung cancer (NSCLC). This is the most common type of lung cancer. Metastatic non-small cell lung cancer (NSCLC) is a type of lung cancer that has spread to other parts of the body, such as the bones, liver, brain, or other organs.

During the treatment, your doctor may periodically monitor your white blood cell counts, platelets, blood sugar, electrolytes, and kidney parameters to prevent serious complications. This medicine has the potential to cause liver damage. Also, it may cause decreased fertility in males and this could affect your ability to father a child. Talk to your healthcare provider if you have concerns about fertility.

Metastatic non-small cell lung cancer (NSCLC)

It works by inhibiting the tyrosine kinases, thus preventing the activation of downstream signalling pathways that are involved in cell proliferation, survival, and differentiation. This leads to the inhibition of cancer cell growth and survival.

Your doctor will decide the dose and duration of Lorbriqua 25mg tablet based on the disease condition and other factors. Take the tablet at the same time every day, with or without food. Do not chew, crush, or break the tablet. Swallow the whole tablet with water. If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

Cough, chest pain, or worsening of breathing problems

Feeling tired, faint, or losing consciousness

Yellowing of the skin and eyes, vomiting, abdominal pain

Confusion, memory loss, mood swings, difficulty speaking, seeing, or hearing things that are not real

Increase in cholesterol levels

Swelling in hand or legs

Double vision difficulty seeing

Pain, numbness, or unusual sensations (burning or pin and needles) in arms and legs, difficulty walking

Diarrhoea, constipation

Headache

Weight gain

Joint pain, muscle pain

Rash

Anaemia

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Lorbriqua 25mg tablet and reduce effectiveness by causing undesirable side effects.

Store Lorbriqua 25mg tablet in the original package at a controlled room temperature (20°C to 25°C).

Keep it out of reach from children.

Lorbriqua 25mg tablet is not recommended for pregnant women as it may cause fetal harm. Consult your doctor if you are pregnant or planning for pregnancy during the treatment. Discuss effective nonhormonal contraceptive methods with your healthcare provider and use them during this treatment and continue for at least six months after the last dose. It is not known if this drug passes into breast milk. Hence, it is not recommended to breastfeed during this treatment. This medicine may increase your blood sugar levels. Your healthcare provider should do blood tests to check your blood sugar levels before starting and during treatment with this drug. It is important to start or change your medicine to control your blood sugar levels. Report to your doctor right away if you get new or worsening signs and symptoms of high blood sugar such as feeling thirsty, confused, and tired. This tablet might cause breathing difficulty and problems with thinking. Hence it is advisable to avoid driving or operating machines during this treatment. Before starting this treatment, inform your doctor if you are taking any prescription medicines, over-the-counter medicines, vitamins, or herbal supplements.