Neukine 300mcg injection contains the active constituent filgrastim. It is a white blood cell growth factor (granulocyte-colony stimulating factor) approved by the FDA to decrease the risk of developing febrile neutropenia ( occurrence of fever or infection associated with low WBC count) and to reduce the duration of neutropenia (low white blood cell count) in people who have non-myeloid cancer and are receiving chemotherapy drugs. It is also used to increase the number of WBC and decrease the length of time of fever in people with acute myeloid leukemia. 

It is also used in people undergoing bone marrow transplants and in people with severe chronic neutropenia (low number of neutrophils in the blood). Neukine 300mcg injection is also used to prepare the blood for leukapheresis (a treatment in which certain blood cells are removed from the blood). It is also indicated to increase the chance of survival in people exposed to harmful amounts of radiation, which can cause severe damage to the bone marrow. Other uses include in patients with advanced HIV infection, which will help to reduce the risk of infections. 

Neukine 300mcg injection belongs to the class of medications called colony-stimulating factors. They work by helping the body to produce more White blood cells. WBC are important because they help your body fight infection. These cells are highly sensitive to the effects of chemotherapy, which might cause a decrease in the number. If your WBC decreases, your body may not have enough cells to combat bacteria, putting you at risk of infection.

To prevent infections after chemotherapy due to decreased white blood cells (neutropenia)

Neukine 300mcg injection is a colony-stimulating factor that acts on blood-forming cells by binding to specific cell surface receptors, thereby inducing cell division, multiplication, and cell functional activation.

Neukine 300mcg injection is available as a prefilled syringe. A qualified healthcare professional will administer the injection in the fatty tissues just under your skin (subcutaneously) or it will be administered as an intravenous injection into your vein slowly. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.  

If your physician decides that you or your caregiver can administer the Neukine 300mcg injection at home, then read the “Instructions for use” carefully from the package insert with the medicine. Your doctor or other healthcare professionals will train you on self-administration. Do not administer the medicine if you have not been trained and are not sure about the administration procedure.

Pain in the bones, joints, and muscles

Pain at the site of Injection

Fever

Itchiness and skin rash

Nausea

Headaches

Dizziness and tiredness

Nose bleeding

Hair fall

Inflammation of Aorta

Capillary leak syndrome (plasma leaks out of tiny blood vessels)

Hypersensitivity reactions

Changes in urine color

Swelling in hands, feet, face, and abdomen

Difficulty in breathing

Sickle cell anemia

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Neukine 300mcg injection and reduce effectiveness by causing undesirable side effects.

Store Neukine 300mcg injection in a refrigerator (2°C – 8°C). Do not freeze.

Do not shake the pre-filled syringe.

Discard the medicine if stored at room temperature for more than 48 hours.

Keep it out of reach from children and pets.

It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor immediately for advice.

Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes. If you use the prefilled syringe, allow the medicine to warm for 30 minutes at room temperature before injecting. Read the package insert carefully if you are self-administering the medicine. This medicine may cause lung, liver, or kidney problems. Your physician may advise you to take laboratory tests regularly to monitor the effectiveness of the therapy.