Oceva Injection contains the active ingredient Ranibizumab. It is an anti-neovascularization agent in the class of medications called vascular endothelial growth factor A (VEGF-A) antagonists. It is used in adults to treat several eye diseases causing vision impairment. It is used to treat wet age-related macular degeneration (AMD, a persistent eye disease that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities).

Oceva Injection is also used to treat myopic choroidal neovascularization (mCNV; a complication in near-sighted people where new blood vessels can grow in the back of the eye) and to treat macular edema after retinal vein occlusion (an eye disease caused by blockage of blood flow from the eye that leads to blurry vision and vision loss). It is also used to treat diabetic macular edema (an eye disease caused by diabetes that can lead to vision loss) and diabetic retinopathy (damage to the eyes caused by diabetes).

Do not use Oceva Injection if you are allergic to Ranibizumab or other ingredients of this medicine. Do not take this medicine if you have an infection in or around your eye and if you have pain or redness in your eye. Inform your doctor immediately if you develop symptoms such as eye pain or increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small particles in your vision, or increased sensitivity to light. Inform your doctor if you have a prior history of eye conditions or eye treatments or had a stroke before initiating the treatment.

Oceva Injection is used to treat several eye diseases causing vision impairment, including,

• Age-related macular degeneration.
• Macular edema.
• Diabetic macular edema and retinopathy.
• Myopic choroidal neovascularization.
• Retinal vein occlusion.

Oceva Injection specifically recognizes and binds to a protein called human vascular endothelial growth factor A (VEGF-A) present in the eye. In excess, VEGF-A causes abnormal blood vessel growth and swelling in the eye, leading to impairment of vision in certain eye diseases. This medicine can block its actions and prevent this abnormal growth and swelling. This injection can help to stabilize and improve your vision.

Oceva Injection is administered as an injection into your eye by an eye doctor under a local anaesthetic. Your doctor will decide the dose and frequency of the injection based on your disease condition. Do not self-administer the medicine.

Serious:

Pain and swelling in the eye

Bleeding in the eye

Blurred vision

Urinary tract infection

Skin rashes

Discharge from the eye

Common:

Tear of the layer in the back of the eye

Flashes of light in the eye

Temporary loss of sight

Clouding of lens

Infection of the eyeball

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications interact with Oceva Injection and reduce its effectiveness by causing undesirable side effects.

• Store in a refrigerator (2°C – 8°C).
• Do not freeze.
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets.

• Not recommended for children or teens—Oceva Injection should not be used in individuals below 18 years of age due to a lack of safety data.
• Elderly patients may need dose adjustments—people over 65 can use this injection but may require modified doses based on their health condition.
• Seek immediate help for eye symptoms—If your eye becomes red, painful, or sensitive to light, or if your vision changes, consult an eye doctor right away.
• Follow-up is important—your doctor will monitor your eye and decide if further injections are needed based on how well you're responding.
• Stick to your doctor’s advice—do not skip or delay your injections. Follow all medical instructions carefully for the best outcome.